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. 2005 Mar 1;115(3):599–609. doi: 10.1172/JCI22304

Figure 5.

Figure 5

Demonstration of gelatinolytic activity in the infarcted myocardium by in situ zymography. Frozen sections were prepared from transverse slices of hearts obtained from vehicle-treated control WT mice (A), TISAM-treated mice sacrificed 6 hours after the last administration of TISAM (B), MMP-2–KO mice (C), and sham-operated WT mice (D) and subjected to in situ zymography as described in Methods. Note the inhibition of gelatinolytic activity in TISAM-treated mouse heart (B) and negligible activity in MMP-2–KO mouse heart (C). Scale bar: 200 μm.