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. 2005 Mar 1;115(3):747–754. doi: 10.1172/JCI22818

Figure 3.

Figure 3

IL-13 R130Q is more active than WT IL-13 in upregulating CD23 expression in primary monocytes. Normal human PBMCs were incubated with increasing concentrations of WT IL-13 (circles) or IL-13 R130Q (triangles) for 48 hours. Surface CD23 expression was then assessed by direct immunofluorescence using PE-conjugated anti-CD23 mAb or isotype control, gating on the monocyte population. Responses to the IL-13 variants were compared using a 2-tailed paired Student’s t test. P values are noted for each IL-13 concentration at which a statistically significant difference in the percentage of CD23+ cells was detected. The figure shows the mean ± SE of the results obtained from 11 experiments.