Table 2.
Kinase Targets in DUD-E
| DUD-E | Symbol | Name | PDB | Family | Total Ligands | Clustered Ligands | Experimental Decoys | Matched Decoys | Resolution (Å) |
|---|---|---|---|---|---|---|---|---|---|
| AKT1 | AKT1 | RAC-alpha serine/threonine-protein kinase | 3CQW | AGC | 585 | 293 | 53 | 16450 | 2.00 |
| AKT2 | AKT2 | RAC-beta serine/threonine-protein kinase | 3D0E | AGC | 234 | 117 | 23 | 6900 | 2.00 |
| KPCB | PRKCB | Protein kinase C beta type | 2I0E | AGC | 331 | 135 | 153 | 8700 | 2.60 |
| ROCK1 | ROCK1 | Rho-associated protein kinase 1 | 2ETR | AGC | 216 | 100 | 15 | 6300 | 2.60 |
| MAPK2 | MAPKAPK2 | MAP kinase-activated protein kinase 2 | 3M2W | CAMK | 184 | 101 | 81 | 6150 | 2.41 |
| CDK2 | CDK2 | Cyclin-dependent kinase 2 | 1H00 | CMGC | 1310 | 474 | 136 | 27850 | 1.60 |
| MK01 | MAPK1 | Mitogen-activated protein kinase 1 | 2OJG | CMGC | 79 | 79 | 35 | 4550 | 2.00 |
| MK10 | MAPK10 | Mitogen-activated protein kinase 10 | 2ZDT | CMGC | 199 | 104 | 23 | 6600 | 2.00 |
| MK14 | MAPK14 | Mitogen-activated protein kinase 14 | 2QD9 | CMGC | 2205 | 578 | 73 | 35850 | 1.70 |
| MP2K1 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | 3EQH | STE | 308 | 121 | 12 | 8150 | 2.00 |
| BRAF | BRAF | Serine/threonine-protein kinase B-raf | 3D4Q | TKL | 317 | 152 | 28 | 9950 | 2.80 |
| TGFR1 | TGFBR1 | TGF-beta receptor type-1 | 3HMM | TKL | 235 | 133 | 7 | 8500 | 1.70 |
| ABL1 | ABL1 | Tyrosine-protein kinase ABL1 | 2HZI | Tyr | 409 | 182 | 84 | 10750 | 1.70 |
| CSF1R | CSF1R | Macrophage colony-stimulating factor 1 receptor | 3KRJ | Tyr | 385 | 166 | 5 | 12150 | 2.10 |
| EGFR | EGFR | Epidermal growth factor receptor | 2RGP | Tyr | 1612 | 542 | 407 | 35050 | 2.00 |
| FAK1 | PTK2 | Focal adhesion kinase 1 | 3BZ3 | Tyr | 101 | 100 | 11 | 5350 | 2.20 |
| FGFR1 | FGFR1 | Fibroblast growth factor receptor 1 | 3C4F | Tyr | 327 | 139 | 146 | 8700 | 2.07 |
| SRC | SRC | Proto-oncogene tyrosine-protein kinase Src | 3EL8 | Tyr | 1269 | 524 | 287 | 34500 | 2.30 |
| VGFR2 | KDR | Vascular endothelial growth factor receptor 2 | 2P2I | Tyr | 2320 | 409 | 142 | 24950 | 2.40 |
| IGF1R | IGF1R | Insulin-like growth factor 1 receptor | 2OJ9 | Tyr | 370 | 148 | 75 | 9300 | 2.00 |
| JAK2 | JAK2 | Tyrosine-protein kinase JAK2 | 3LPB | Tyr | 246 | 130 | 6 | 6500 | 2.00 |
| KIT | KIT | Mast/stem cell growth factor receptor Kit | 3G0E | Tyr | 378 | 166 | 8 | 10450 | 1.60 |
| LCK | LCK | Tyrosine-protein kinase Lck | 2OF2 | Tyr | 916 | 420 | 148 | 27400 | 2.00 |
| MET | MET | Hepatocyte growth factor receptor | 3LQ8 | Tyr | 333 | 166 | 17 | 11250 | 2.02 |
| PLK1 | PLK1 | Serine/threonine-protein kinase PLK1 | 2OWB | Other | 227 | 107 | 46 | 6800 | 2.10 |
| WEE1 | WEE1 | Wee1-like protein kinase | 3BIZ | Other | 221 | 102 | 15 | 6150 | 2.20 |