Table 3.
Kinase Targets in SARfari
| Symbol | Name | Family | SARfari Compounds | Clustered Compounds |
|---|---|---|---|---|
| AKT3 | RAC-gamma serine/threonine-protein kinase | AGC | 91 | 32 |
| CDK1 | Cyclin-dependent kinase 1 | CMGC | 797 | 383 |
| CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | Other | 92 | 49 |
| CLK4 | Dual specificity protein kinase CL4 | CMGC | 70 | 32 |
| FLT4 | Vascular endothelial growth factor receptor 3 | Tyr | 102 | 68 |
| GSK3A | Glycogen synthase kinase-3 alpha | CMGC | 269 | 126 |
| LIMK2 | LIM domain kinase 2 | TKL | 43 | 15 |
| MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | STE | 122 | 47 |
| PDGFRA | Platelet-derived growth factor receptor alpha | Tyr | 287 | 136 |
| PDGFRB | Platelet-derived growth factor receptor beta | Tyr | 523 | 218 |
| PHKG1 | Serine/threonine-protein kinase PHKG1 | CAMK | 43 | 9 |
| PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | AGC | 89 | 38 |
| PRKCD | Protein kinase C delta type | AGC | 452 | 132 |
| PRKCE | Protein kinase C epsilon type | AGC | 223 | 82 |
| PRKCG | Protein kinase C gamma type | AGC | 204 | 64 |
| PRKCZ | Protein kinase C zeta type | AGC | 104 | 34 |
| PRKD1 | Serine/threonine-protein kinase D1 | CAMK | 104 | 40 |
| PRKD3 | Serine/threonine-protein kinase D3 | CAMK | 101 | 38 |
| RAF1 | RAF proto-oncogene serine/threonine-protein kinase | TKL | 269 | 129 |
| YES1 | Tyrosine-protein kinase Yes | Tyr | 50 | 33 |