Table 5.

Kinase Targets in SARfari and Parameters for Building Homology Models

	High Identity Homology Model						Low Identity Homology Model
Symbol	Template PDB	Template Symbol	Scorea	Identitiesb	Positivesc	Gapsd	Template PDB	Template Symbol	Scorea	Identitiesb	Positivesc	Gapsd
AKT3	1GZN	AKT2	485.3	87%	95%	0%	1UU9	PDPK1	186.4	39%	60%	0%
CDK1	4EK4	CDK2	406.8	64%	78%	3%	4G6O	MAPK1	184.1	36%	53%	5%
CHUK	4KIK	IKBKB	386.7	64%	77%	1%	4B9D	NEK1	103.6	31%	52%	5%
CLK4	1Z57	CLK1	584.7	86%	92%	0%	1UKI	MAPK8	108.6	29%	46%	15%
FLT4	3VID	KDR	454.9	69%	79%	0%	4FOB	ALK	165.2	33%	47%	19%
GSK3A	1J1B	GSK3B	607.1	86%	93%	0%	3R71	CDK2	177.9	36%	58%	10%
LIMK2	3S95	LIMK1	408.3	69%	83%	2%	2J0L	PTK2	105.1	27%	47%	15%
MAP3K8	3GGF	STK26	145.2	34%	56%	5%	4FZA	STK26	141.8	34%	56%	5%
PDGFRA	3HNG	VEGFR1	340.1	47%	65%	9%	2RFN	MET	43.5	31%	45%	9%
PDGFRB	1Y6A	VEGFR2	323.6	46%	61%	10%	4F64	FGFR1	104.0	45%	61%	1%
PHKG1	2Y7J	PHKG2	421.8	70%	85%	0%	3R2B	MAPKAPK2	150.6	33%	52%	11%
PRKACG	2F7E	PRKACA	473.4	86%	94%	0%	4EL9	RPS6KA3	200.3	37%	63%	2%
PRKCD	1XJD	PRKCQ	512.3	72%	84%	0%	3NX8	PRKACA	191.0	40%	60%	1%
PRKCE	3TXO	PRKCH	525.8	69%	82%	0%	3AMB	PRKACA	203.8	40%	60%	2%
PRKCG	3IW4	PRKCA	559.7	75%	87%	1%	4L45	RPS6KB1	223.8	41%	63%	3%
PRKCZ	3ZH8	PRKCI	497.7	88%	94%	0%	3OTU	PDPK1	162.9	33%	54%	4%
PRKD1	2W0J	CHEK2	193.4	38%	60%	6%	4AE9	PRKACA	146.4	35%	57%	7%
PRKD3	2W0J	CHEK2	194.1	39%	61%	6%	2GNL	PRKACA	141.7	34%	55%	7%
RAF1	3D4Q	BRAF	496.5	77%	89%	0%	2Y4I	KSR2	162.9	35%	56%	5%
YES1	2H8H	SRC	485.0	89%	95%	0%	3K54	BTK	218.8	40%	64%	0%
Mean			425.1	68%	81%	2%			156.1	35%	55%	6%

^aBLAST bit score;

^bPercentage of residues that are identical between the sequences;

^cPercentage of residues that are positive matches according to the similarity matrix;

^dPercentage of gaps in both query and homolog as returned by BLAST.