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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: J Comp Physiol B. 2017 Mar 23;187(5-6):815–825. doi: 10.1007/s00360-017-1081-x

Figure 1.

Figure 1

Adhesion and aggregation of platelets. Platelets adhere to a damaged vessel wall through binding of their glycoprotein Ib (GpIbα) receptor to von Willebrand Factor (vWF) which in turn binds to exposed collagen. Platelet aggregation occurs when two platelets bind to a single molecule of fibrinogen through their glycoprotein IIb/IIIa receptors (GpIIb/IIIa). Glycosylated proteins on the surface of the platelets also contain sialic acid caps, and the removal of these lead to clearance through Ashwell Morell receptors on hepatocytes.