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Mortality parameter analyses of animal treated with free or liposomal DOX
| Groups | Survival median (days) | vs. control | vs. SpHL-AL-DOX | ||
|---|---|---|---|---|---|
|
| |||||
| p-value | risk ratio | p-value | risk ratio | ||
| Healthy animals | |||||
| Control | > 28 | - | - | 1.0000 | 1.000 |
| SpHL-DOX | > 28 | 0.1410 | 5.618 | 0.0628 | 8.650 |
| SpHL-AL- | > 28 | 1.0000 | 1.000 | - | - |
| DOX | |||||
| DOX | 12.5 | 0.0364 | 6.944 | 0.0087 | 11.236 |
| Tumor bearing animals | |||||
| Control | 25 | - | - | 0.0473 | 4.416 |
| SpHL-DOX | > 28 | 0.0741 | 0.269 | 0.9828 | 1.022 |
| SpHL-AL- | > 28 | 0.0473 | 0.226 | - | - |
| DOX | |||||
| DOX | > 28 | 0.6516 | 0.755 | 0.1125 | 3.461 |
