Table 1. OGH-TG mice have reduced cholesterol, insulin, and TSH levels and increased levels of thyroid hormone.
Male
|
Female
|
|||
---|---|---|---|---|
Measurement | WT | OGH-TG | WT | OGH-TG |
Body weight, g | 31.6 ± 3.1 | 26.8 ± 3.6* | 26.4 ± 3.2 | 20.5 ± 2.5* |
Glucose, mg/dl | 277 ± 10 | 214 ± 25* | 214 ± 10 | 213 ± 17 |
Triglycerides, mg/dl | 121 ± 15 | 76 ± 7* | 80 ± 11 | 76 ± 6 |
Cholesterol, mg/dl | 118 ± 9 | 71 ± 7* | 90 ± 5 | 69 ± 6* |
Insulin, ng/ml | 2.5 ± 0.18 | 1.9 ± 0.15* | ND | ND |
TSH, ng/ml | (174 ± 13) | (132 ± 5*) | 95 ± 3 | 93 ± 9 |
T3, ng/dl | (84 ± 5) | (130 ± 10*) | 69 ± 7 | 119 ± 14* |
T4 μg/dl | (2.8 ± 0.2) | (6.9 ± 1.1*) | 3.5 ± 0.3 | 5.7 ± 1.0* |
Groups of male and female mice were fasted overnight and killed on the next morning for serum collection. Mice were 5 months old, except for values in parentheses, for which the mice were 2 months old. ND, no data. *, P<0.05, compared with WT littermate controls (one-way ANOVA).