Table 2.

The Grading of Recommendations, Assessment, Development and Evaluations (GRADE) Criteria was used to assess the level of evidence for each outcome

Outcomes	Type of Evidence	Quality	Consistency	Directness	Effect Size	Total	Overall Quality
Local Control	+2	−2	0	0	0	0	Very low
Distant Progression	+2	−2	0	0	0	0	Very low
LMD	+2	−2	−1	0	+1	0	Very low
Overall Survival	+2	−2	−1	0	0	−1	Very low

Type of evidence is based on the study design of the included studies and ranges from +2 to +4. Study quality is graded based on blinding and allocation, follow up and withdrawals, sparsity of data, or methodological concerns and ranges from −3 to 0. Consistency is graded based on heterogeneity of populations and study end points with respect to one another and included populations and ranges from −1 to +1. Directness is graded based on generalizability of the included results and is graded from −2 to 0. Effect size is graded on the value of the RR or OR and is graded from 0 to +2. The overall quality of the recommendations that can be made based on the included studies includes the following categories: high (at least 4 points overall), moderate (3 points), low (2 points), and very low (1 point or less)