Table 1.

Characteristics of Common Exercise Tests

Exercise Test	Pacing	End Point	Principal Measurement	Adjunct Measurements	Intensity	Complexity	Relationship to ${\dot{\mathrm{V}}}_{{\mathrm{O}}_2}\text{peak}/max$	Relationship to PA	Relationship to PRO	Relationship to Clinical Outcomes
CPET20	Externally paced	Prohibitive symptoms or plateau of ${\dot{\mathrm{V}}}_{{\mathrm{O}}_2}$	${\dot{\mathrm{V}}}_{{\mathrm{O}}_2}$	${\dot{\mathrm{V}}}_{{\text{CO}}_2}$, VE, AT, HR, BP, O2 saturation, work	+++	+++	–	–	–	–
6MWT23,24	Self-paced	6-min duration	Distance	HR, BP, O2 saturation, desaturation indices, work	++	+	Moderate-strong	Moderate-strong	Weak-moderate	Consistently strong
ESWT23,24	Externally paced	Prohibitive symptoms or 20-min duration	Time	HR, O2 saturation, distance	++	++	N/A	N/A	N/A	N/A
ISWT23,24	Externally paced	Prohibitive symptoms or 12 total stages	Distance	HR, O2 saturation, ${\dot{\mathrm{V}}}_{{\mathrm{O}}_2}$ VE	++	++	Strong	Weak-moderate	N/A	Suggestive
SCT	Self-paced	Volitional exhaustion or designated height/flights of stairs	Height	HR, O2 saturation, time	++	+	Moderate-strong	N/A	N/A	N/A

Note: In general, not specific to lung cancer.

6MWT, 6-minute walk test; AT, anaerobic threshold; BP, blood pressure; CPET, cardiopulmonary exercise testing; ESWT, endurance shuttle walk test; ISWT, incremental shuttle walk test; HR, heart rate; O₂, oxygen; PA, physical activity; PRO, patient-reported outcome; SCT, stair-climbing test; VE, minute ventilation; ${\dot{\mathrm{V}}}_{{\mathrm{O}}_2}$, oxygen consumption; min, minute.