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Effects of local irradiation and POLY-MVA on cardiac structure. Representative micrographs of histology and the quantification of cardiac area occupied by collagens, cardiac mast cell numbers and microvessel density are shown. Radiation caused an increase in cardiac collagen deposition, cardiac mast cell numbers, and a decrease in myocardial microvessel density. POLY-MVA did not mitigate these effects. Data are presented as average ± SD, n = 8–9. *P < 0.05 when compared to 5 × 0 Gy.
