Skip to main content
. Author manuscript; available in PMC: 2018 Mar 17.
Published in final edited form as: ACS Synth Biol. 2017 Feb 22;6(3):421–427. doi: 10.1021/acssynbio.6b00341

Figure 1. Kirromycin assembly line and the production of new kirromycin derivatives.

Figure 1

A: acyltransferase ACP: acyl carrier protein, KS: ketosynthase, DH: dehydrogenase, KR: ketoreductase, MT: methyltransferase, ER: enoylreductase, C: condensation domain, A: adenylation domain, PCP: peptidyl carrier protein, MatB: engineered malonyl-CoA synthetase (T207G/M306I), KirCII: discrete acyltransferase and R: functional group. Kirromycin (1), allyl-kirromycin (2), propargyl-kirromycin (3) and coumarin-kirromycin (4).