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. 2005 Jan 28;33(2):622–631. doi: 10.1093/nar/gki182

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© The Author 2005. Published by Oxford University Press. All rights reserved

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Class IV ribozyme artificial phylogeny and predicted secondary structure. (A) Primary sequence of the metal-binding domain is shown for ribozymes isolated from reselection on initial populations where 18% degeneracy was introduced into the metal-binding domain. (B) Sequence and secondary structure model of the parental class IV ribozyme. (C) Standard ribozyme assays conducted on parental (Par.) or mutant (M1, M2) ribozymes containing either disruptive (M1, M3) or compensatory (M2, M4) mutations (boxed). Open and closed arrowheads indicated trace radiolabeled full-length precursor or cleaved product, respectively.