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Some physicochemical characteristics of the metal ions used in this study. Metal ions are classified according to (A) ionic radius (B) pKa of metal-bound water (C) hydration enthalpy and (D) ‘hard’ versus ‘soft’ character. Red and black circles reflect cations that are active or inactive, respectively, as allosteric effectors for the class II ribozyme. Plots of physical parameters were generated from parameters published elsewhere (35).
