Table 3.
Methods | Unadjusted | Model 1 | Model 2 | Model 3 | ||||
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HR (95%CI) | p | HR (95%CI) | p | HR (95%CI) | p | HR (95%CI) | p | |
Low muscle mass by each criteria and low grip strength | ||||||||
| ||||||||
Low muscle mass by Height2 | 4.23 (2.11–8.49) | 0.001 | 2.61 (1.18–5.73) | 0.02 | 2.83 (1.27–6.33) | 0.01 | 2.23 (0.99–5.00) | 0.05 |
+ weakness | C = 0.55 | C = 0.64 | C = 0.65 | C = 0.73 | ||||
Low muscle mass by BW | 2.51 (1.46–4.31) | 0.001 | 1.60 (0.82–3.10) | 0.17 | 1.59 (0.82–3.07) | 0.17 | 1.24 (0.63–2.43) | 0.54 |
+ weakness | C = 0.56 | C = 0.63 | C = 0.64 | C = 0.72 | ||||
Low muscle mass by BSA | 2.58 (1.58–4.20) | 0.001 | 1.77 (0.97–3.22) | 0.06 | 1.83 (1.00–3.33) | 0.05 | 1.53 (0.84–2.78) | 0.16 |
+ weakness | C = 0.58 | C = 0.64 | C = 0.65 | C = 0.73 | ||||
Low muscle mass by BMI | 2.46 (1.48–4.09) | 0.001 | 1.69 (0.91–3.14) | 0.10 | 1.72 (0.92–3.20) | 0.09 | 1.65 (0.88–3.08) | 0.12 |
+ weakness | C = 0.56 | C = 0.62 | C = 0.64 | C = 0.72 | ||||
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Low muscle mass by each criteria and slow gait speed | ||||||||
| ||||||||
Low muscle mass by Height2 | 4.86 (2.42–9.76) | 0.001 | 3.23 (1.52–6.85) | 0.002 | 3.31 (1.54–7.12) | 0.002 | 2.92 (1.33–6.41) | 0.01 |
+ slowness | C = 0.56 | C = 0.64 | C = 0.65 | C = 0.73 | ||||
Low muscle mass by BW | 2.67 (1.61–4.40) | 0.001 | 1.94 (1.09–3.45) | 0.03 | 1.85 (1.03–3.31) | 0.04 | 1.56 (0.85–2.83) | 0.15 |
+ slowness | C = 0.57 | C = 0.64 | C = 0.64 | C = 0.72 | ||||
Low muscle mass by BSA | 2.63 (1.59–4.33) | 0.001 | 1.84 (1.04–3.27) | 0.04 | 1.79 (1.01–3.17) | 0.04 | 1.46 (0.83–2.58) | 0.19 |
+ slowness | C = 0.58 | C = 0.64 | C = 0.64 | C = 0.73 | ||||
Low muscle mass by BMI | 3.35 (2.05–5.45) | 0.001 | 2.62 (1.48–4.66) | 0.001 | 2.55 (1.43–4.54) | 0.002 | 2.51 (1.41–4.66) | 0.002 |
+ slowness | C = 0.58 | C = 0.64 | C = 0.64 | C = 0.73 |
BW, body weight; BMI, body mass index; BSA, body surface area; C, C-statistic; HR, hazard ratio; 95% CI, 95% confidence interval.
Model 1: Adjusted for age, sex, and race; Model 2: Adjusted for age, sex, race, and comorbidities (diabetes mellitus, congestive heart failure, coronary artery disease); Model 3: Further adjusted for serum albumin.