Although de-noising approaches remove motion artifact from BOLD time series, it is
possible that they also remove signal of interest. We quantified the retention of signal
of interest as the modularity quality of the de-noised connectome.
A, The modularity quality in a 264-node network defined
by Power et al. (2011) following confound
regression. B, The modularity quality in a second, 333-node
network defined by Gordon et al. (2016). ICA-,
GSR-, and tissue class-based models performed relatively well, while models that included
realignment parameters alone did not remove enough noise to accurately identify network
structure.