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. 2017 Jun 26;8:669. doi: 10.3389/fimmu.2017.00669

Figure 4.

Figure 4

Typical colitis in WT mice caused by dextran sulfate sodium (DSS) treatment were not observed in CD169-diphtheria toxin receptor (DTR) mice. WT and CD169-DTR mice with diphtheria toxin treatment were both orally treated with 3.5% DSS; 7 days later, mice were harvested. (A) Weight loss of WT mice (n = 5) and CD169-DTR mice (n = 5) treated with the indicated time points with DSS, *P < 0.05, ***P < 0.001compared to control. (B) Macroscopic observation of colons on day 7, such as the length of colons and bloody stools (left), and the statistical analysis of the length of WT colitis and CD169-DTR colitis mice colons (right) (n = 10), ***P < 0.001 compared to control. (C) Immunohistochemistry analysis of mesenteric lymph node sections obtained from WT colitis mice and CD169-DTR colitis mice. Data are representative of two independent experiments.