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. 2017 Jun 26;8:408. doi: 10.3389/fphar.2017.00408

FIGURE 6.

FIGURE 6

(A) Representative voltage-clamp recordings from Xenopus oocytes expressing hKCNK3, before, during and after the application of 1 mM of 1-[1-oxo-9(3,4-methylenedioxyphenyl)-2E,4E,8E-nonatrienyl]-pyrrolidine (3b) (top); brachyamide A (4b) (middle) and 1-(octadeca-2E,4E,13/12Z-trienoyl)pyrrolidine (5b/6b) (bottom). The dotted line represents zero current. (B) Dose-response curves for the effect of 1-[1-oxo-9(3,4-methylenedioxyphenyl)-2E,4E,8E-nonatrienyl]-pyrrolidine (3b) (black squares); brachyamide A (4b) (red circles) and 1-(octadeca-2E,4E,13/12Z-trienoyl)-pyrrolidine (5a/6a) (blue triangles) on hKCNK3. See Table 1 for IC50 values. N = 3–5 oocytes.