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. 2017 Jun 26;8:408. doi: 10.3389/fphar.2017.00408

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Copyright © 2017 Beltrán, Dawid, Beltrán, Levermann, Titt, Thomas, Pürschel, Satalik, Gisselmann, Hofmann and Hatt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The dose-response relationship for piperlonguminine (a, 1c), piperyline (b, 1b), piperettine (c, 1c), dehydropipernonaline (d, 3a), guineensine (e, 4c), (2E,4E,13/12Z)-N-isobutyl-octadeca-2,4,12/13-trienamide (f, 5c/6c), 1-(octadeca-2E,4E,13/12Z-trienyl)piperidine (g, 5a/6a) and (2E,4E)-N-isobutyl-octadeca-2,4-dienamide (h, 7c) on Xenopus oocytes expressing hKNCK3. N = 3–6 oocytes. The dose-response curve for piperine on hKCNK3 (gray curve) from Beltrán et al., 2013 is presented for comparison purposes.