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. 2017 Jun 26;8:408. doi: 10.3389/fphar.2017.00408

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Copyright © 2017 Beltrán, Dawid, Beltrán, Levermann, Titt, Thomas, Pürschel, Satalik, Gisselmann, Hofmann and Hatt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Left: A representative voltage-clamp recording from a Xenopus oocyte expressing hKCNK9, before, during and after the application to 1 mM of 1-(octadeca-2E,4E,13/12Z-trienoyl)pyrrolidine (5b/6b). Right: Dose-response curves for the effect of 1-(octadeca-2E,4E,13/12Z-trienoyl) pyrrolidine (5b/6b) on hKCNK9. The IC₅₀ value is 236 ± 56 μM. N = 3–6 oocytes. (B) Left: A representative voltage-clamp recording from a Xenopus oocyte expressing hKCNK18, before, during and after the application to 1 mM of piperyline (1b). Right: Dose-response curves for the effect of piperyline (1b) on hKCNK18. The IC₅₀ value is 252 ± 55 μM. N = 3–6 oocytes. The dose-response curve for piperine (1a) (gray diamonds) on each channel is presented for comparison.