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. 2017 Jun 26;7:127. doi: 10.3389/fonc.2017.00127

Figure 6.

Figure 6

Intracranial injection of oncolytic viruses. (A) 1 × 105 primary glioma sphere cells were stereotactically implanted into the corpus striatum of NOD-SCID mice. After 5 days, 2 × 105 TCID50 of the indicated viruses in 5 µl PBS or PBS were stereotactically injected into the same coordinates. Health status and body weight were monitored daily. Mice were sacrificed with onset of neurological symptoms and/or loss of weight by more than 20%. Based on the defined end points Kaplan–Meier survival plots were generated. PBS, n = 4; measles virus (MV)-CD46/CD133, n = 4; vesicular stomatitis virus (VSV)-CD133, n = 5. (B) 2 × 105 TCID50 of VSV-CD133, UV-inactivated (UV) VSV-CD133, or VSV-MV in 5 µl PBS, respectively, were stereotactically injected into the corpus striatum of NOD-SCID mice. Health status and body weight were monitored daily. Mice were sacrificed with onset of neurological symptoms and/or weight loss of more than 20%, n = 5.