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. 2017 Jun 26;8:687. doi: 10.3389/fimmu.2017.00687

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Copyright © 2017 Tao, Mahalingam, Zhu, Moayeri, Kirtley, Fitts, Andersson, Lawrence, Leppla, Chopra and Rao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The F1mutV-protective antigen (PA) triple antigen is highly immunogenic in rats. (A) Vaccine formulations used in various immunized Brown Norway rat groups. The protein combinations used for each group are shown. (B) The immunization scheme. Rats (n = 9) were immunized (intramuscular) on days 0 and 21. Sera were collected on days 0 and 35 for antibody analysis. Animals were challenged with Yersinia pestis (intranasal) on day 42 followed by lethal toxin (LeTx) (intravenous) on day 111. (C) F1V-specific antibody titers. (D) PA-specific antibody titers. (E) LeTx-neutralizing antibody titers. Error bars represent SD.