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. 2017 Jun 26;8:687. doi: 10.3389/fimmu.2017.00687

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Copyright © 2017 Tao, Mahalingam, Zhu, Moayeri, Kirtley, Fitts, Andersson, Lawrence, Leppla, Chopra and Rao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The triple antigen vaccine provides complete protection in the New Zealand White rabbit model of inhalation anthrax. (A) Vaccine formulations used in various New Zealand White rabbit groups. The protein combinations used for each group are shown. (B) Immunization scheme for rabbit study. Rabbits (n = 10 for group 1, and n = 6 for groups 2 and 3, equal numbers of males and females) were immunized on day 0 and given a boost on day 14. Animals were challenged with 200 LD₅₀ of aerosolized Bacillus anthracis Ames spores 2 weeks after the boost. (C) Protective antigen (PA)-specific antibody titers. Titers for bleeds on days 0, 12, 20, and 42 are shown. (D) Lethal toxin-neutralizing antibody titers. (E,F) F1V-specific antibody titers. Titers are shown for day 20 (E) and day 42 (F). (G) Survival of the rabbits challenged with 200 LD₅₀ of aerosolized B. anthracis Ames spores. Error bars represent SD of the mean.