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Effect of CENP-B box density on rate of HAC formation
| Vector | No. of CENP-B boxes | No. of experiments | No. of clones analyzed | No. of clones with HACsa | HAC formation (%) |
|---|---|---|---|---|---|
| pBAC17α32-all | 16 | 15 | 45 | 10 | 22 |
| pBAC17α32-natural | 5 | 6 | 38 | 4 | 10.5 |
| pBAC17α32-null | 0 | 10 | 40 | 1 | 2.5 |
aCytogenetically detectable. Validated by FISH and mitotic stability (see Materials and Methods).
