Figure 6.

Surface hydrophobicity levels of β-hairpin AMPs. Red: more hydrophobic; white: less hydrophobic according to a normalized consensus hydrophobicity scale [202]. Side views of each hairpin after 200 ps of MD simulation in water and 300 minimization steps: (a) protegrin-1; (b) θ-defensin; (c) tachyplesin; (d) polyphemusin; (e) gomesin; (f) androctonin; (g) YGKRGF; (h) AGGKGF. The latter two are from the combinatorial library in [203]. All peptides are oriented with the more hydrophobic side to the left and the turn region down. The black lines denote the borders of a 26-Å-thick membrane region with transmembrane insertion. The molecular graphics were produced using VMD 1.9.2 [204].