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Single-molecule picometer-resolution nanopore tweezers (SPRNT). (a) A ssDNA:helicase complex is captured in the MspA pore. (b) Consensus of current level patterns for the shown DNA sequence using Φ29 DNA polymerase (left) or Hel308 helicase (right). Φ29 polymerase moves DNA base-by-base through the pore, while Hel308 shows intermediate current steps. Adapted by permission from Macmillan Publishers Ltd: Nature Biotechnology [68], copyright © 2015.
