Table 2.
Over-represented hexamers in the proximal downstream intron region D400
| Sequence | Brain frequency ×10−3 (rank) | Control frequency ×10−3 (rank) | Contrast score | P-value |
|---|---|---|---|---|
| Human | ||||
| UGCAUG | 2.53 (1) | 0.25 (1310) | 2.29 | 0.031* |
| UUUUAA | 1.72 (2) | 0.28 (1103) | 1.44 | 0.240 |
| UUUGUU | 1.72 (2) | 0.39 (718) | 1.33 | 0.301 |
| UUGUUU | 1.63 (5) | 0.36 (822) | 1.28 | 0.343 |
| UGUUUU | 1.72 (2) | 0.45 (555) | 1.27 | 0.347 |
| UGCUUU | 1.63 (5) | 0.37 (759) | 1.26 | 0.357 |
| UUUUAU | 1.45 (7) | 0.21 (1563) | 1.24 | 0.375 |
| UCAUUU | 1.36 (9) | 0.22 (1459) | 1.14 | 0.494 |
| UUUAUU | 1.36 (9) | 0.24 (1384) | 1.12 | 0.506 |
| GCAUGC | 1.27 (11) | 0.20 (1597) | 1.07 | 0.580 |
| Mouse | ||||
| UGCAUG | 2.36 (1) | 0.54 (283) | 1.81 | 0.030* |
| CUGCAU | 1.45 (5) | 0.38 (836) | 1.07 | 0.391 |
| UUUCUG | 1.72 (2) | 0.66 (124) | 1.07 | 0.396 |
| AUUUUA | 1.36 (7) | 0.41 (706) | 0.95 | 0.575 |
| UUUAAA | 1.27 (9) | 0.42 (627) | 0.85 | 0.803 |
| CAUUUG | 1.09 (20) | 0.28 (1512) | 0.81 | 0.867 |
| UGAUUU | 1.09 (20) | 0.35 (1016) | 0.74 | 0.964 |
| ACCAGG | 1.18 (13) | 0.44 (561) | 0.74 | 0.969 |
| UGCUUU | 1.18 (13) | 0.45 (528) | 0.73 | 0.974 |
| UUUUAA | 1.18 (13) | 0.45 (482) | 0.71 | 0.983 |
| Rat | ||||
| UGCAUG | 3.03 (1) | 0.46 (374) | 2.56 | 0.028* |
| CUGCAU | 2.05 (2) | 0.30 (1283) | 1.75 | 0.119 |
| UGCUUC | 1.46 (4) | 0.43 (468) | 1.03 | 0.543 |
| UGUCUG | 1.66 (3) | 0.67 (53) | 0.99 | 0.594 |
| GCAUGC | 1.17 (15) | 0.29 (1453) | 0.89 | 0.780 |
| GCAUGU | 1.17 (15) | 0.36 (791) | 0.81 | 0.908 |
| UCGCUG | 0.88 (54) | 0.08 (3151) | 0.79 | 0.927 |
| CCCUCU | 1.37 (6) | 0.58 (112) | 0.78 | 0.941 |
| CCCACC | 1.27 (9) | 0.50 (264) | 0.76 | 0.958 |
| CUGAUU | 1.07 (25) | 0.31 (1192) | 0.76 | 0.962 |
| Dog | ||||
| UGCAUG | 2.73 (1) | 0.25 (1310) | 2.49 | 0.024* |
| UGUUUU | 1.76 (2) | 0.45 (555) | 1.31 | 0.360 |
| UUUGUU | 1.66 (3) | 0.39 (718) | 1.27 | 0.391 |
| UUUUUG | 1.66 (3) | 0.44 (588) | 1.22 | 0.447 |
| UGCUUU | 1.56 (5) | 0.37 (759) | 1.19 | 0.488 |
| AUUUUU | 1.56 (5) | 0.40 (685) | 1.16 | 0.521 |
| UCCUUU | 1.46 (8) | 0.32 (935) | 1.14 | 0.552 |
| UUUAUU | 1.37 (9) | 0.24 (1384) | 1.13 | 0.565 |
| UUUGCU | 1.37 (9) | 0.30 (1041) | 1.07 | 0.654 |
| CUGCAU | 1.37 (9) | 0.30 (1023) | 1.06 | 0.663 |
| Chicken | ||||
| UGCAUG | 2.12 (2) | 0.50 (340) | 1.62 | 0.017* |
| UGUUUU | 2.22 (1) | 1.02 (4) | 1.19 | 0.199 |
| GUUUUU | 1.69 (4) | 0.71 (52) | 0.98 | 0.553 |
| UUUGUU | 1.80 (3) | 0.91 (13) | 0.89 | 0.778 |
| UUUUUU | 1.69 (4) | 0.84 (19) | 0.85 | 0.859 |
| CAUGCU | 1.27 (14) | 0.44 (515) | 0.83 | 0.906 |
| AUGCAU | 1.16 (19) | 0.36 (890) | 0.80 | 0.941 |
| CUUUUU | 1.48 (8) | 0.69 (62) | 0.79 | 0.951 |
| UAUAUA | 0.95 (53) | 0.19 (2299) | 0.77 | 0.977 |
| UGGUUC | 0.95 (53) | 0.21 (2089) | 0.74 | 0.987 |
| Fugu | ||||
| UGCAUG | 3.00 (1) | 0.61 (227) | 2.39 | 0.010* |
| UUAAAU | 1.62 (6) | 0.22 (1635) | 1.39 | 0.789 |
| CCAUUU | 1.62 (6) | 0.28 (1290) | 1.34 | 0.807 |
| UUUUUC | 2.08 (2) | 0.77 (76) | 1.30 | 0.884 |
| GGAUGG | 1.38 (16) | 0.11 (2562) | 1.27 | 0.893 |
| AAAUGG | 1.38 (16) | 0.11 (2562) | 1.27 | 0.893 |
| UGUGUG | 1.85 (4) | 0.61 (227) | 1.24 | 0.956 |
| UUGCAU | 1.62 (6) | 0.39 (757) | 1.23 | 0.956 |
| AUAAUC | 1.38 (16) | 0.17 (2041) | 1.22 | 0.956 |
| CUUUUU | 1.85 (4) | 0.66 (163) | 1.18 | 0.964 |
*Indicates results that are statistically significant (P-value < 0.05).