Table 2.

Inhibitors of Appr1p phosphatase activity of Poa1p^a

Competitor	IC50
ADPR	30 μM
AppA	1 mM
NAD	1.5 mM
NADP	2 mM
ADP	>10 mM
3′pA	>10 mM
2′pC	>10 mM
5′3′pAp	NDb
5′pA	ND
2′pA	ND
2′pG	ND
3′pG	ND
3′pC	ND
ribose-1p	ND
ribose-5p	ND
glucose-1p	ND
fructose-6p	ND
glyceraldehyde-3p	ND

^aFor surveys at 10 mM competitor, 8 nM Poa1p, 26 nM Appr1p, 1 h; and 35 nM Poa1p, 5 μM Appr1p, 2 h; for IC₅₀ values, 35 nM Poa1p, 5 μM Appr1p, 2 h.

^bND, no detected inhibition in survey at 10 mM.