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Rate constants and dissociation constants of aptamer 3-07 mutants against domain IIId of HCV IRES
| 3-07 mutant | kon (×104 M−1 s−1) | koff (×10−4 s−1) | KD (nM) |
|---|---|---|---|
| 3-07(GGG) | ND | ND | ND |
| 3-07(GGAAAG) | 0.53 ± 0.2 | 5.5 ± 2 | 110 ± 40 |
| 3-07(C51G) | 4.0 ± 0.8 | 3.7 ± 0.6 | 9.5 ± 0.6 |
| 3-07(29-65) | 0.42 ± 0.1 | 13 ± 1 | 330 ± 100 |
ND: binding response was not detected.
