Table 3.

Hypothetical forms for complex heritability from Mendelian nephrotic syndrome (NS) genes

Form of Inheritance	Description	Example
“Risk Allele”	Heterozygosity for a variant in a recessive NS gene OR heterozygosity for a variant in a dominant NS gene that does not fulfill characteristics of a Mendelian allele, whether in terms of allele frequency, conservation, or predicted impact on function	Heterozygosity for MYO1E p.I384T
“Oligogenicity”	Heterozygosity for a single pathogenic allele in multiple genes. Each variant allele is alone solely insufficient to cause phenotype but combined effect contributes to phenotype	Heterozygous for CD2AP p.M496I, AND heterozygous for NPHS2 p.A208T