Table 5.
Analysis of burden of at least one variant in any of the 21 monogenic nephrotic syndrome (NS) genes in clinically defined subgroup of participants. Statistical analysis was performed using two-tailed Fisher’s exact test.
| p-value | |||
|---|---|---|---|
|
| |||
| Pediatric NS vs 1000G | Ped NS (n=98) | 1000G (n=2498) | |
| Stringent Filter | 12 (12%) | 384 (15%) | 0.48 |
| Relaxed Filter | 57 (58%) | 1699 (68%) | 0.04 |
|
| |||
| Pediatric FSGS vs 1000G | Ped FSGS (n=30) | 1000G (n=2498) | |
| Stringent Filter | 2 (7%) | 384 (15%) | 0.3 |
| Relaxed Filter | 14 (47%) | 1699 (68%) | < 0.01 |
|
| |||
| Pediatric MCD vs 1000G | Ped MCD (n=44) | 1000G (n=2498) | |
| Stringent Filter | 8 (18%) | 384 (15%) | 0.53 |
| Relaxed Filter | 35 (80%) | 1699 (68%) | 0.14 |
|
| |||
| Pediatric Complete Remission History | Yes CR (n=63) | No CR (n=35) | |
| Stringent Filter | 8 (67%) | 4 (33%) | 0.22 |
| Relaxed Filter | 38 (66%) | 20 (33%) | 0.01 |
|
| |||
| Pediatric FSGS vs Pediatric MCD | Pediatric FSGS (n=30) | Pediatric MCD (n=44) | |
| Stringent Filter | 2 (7%) | 8 (18%) | 0.19 |
| Relaxed Filter | 14 (47%) | 35 (80%) | < 0.01 |
|
| |||
| FSGS+MCD vs 1000G | FSGS+MCD (n=162) | 1000G (n=2498) | |
| Stringent Filter | 23 (14%) | 384 (15%) | 0.82 |
| Relaxed Filter | 108 (58%) | 1699 (68%) | 0.73 |
|
| |||
| FSGS + MCD (Ped) vs 1000G | FSGS+MCD (n=74) | 1000G (n=2498) | |
| Stringent Filter | 10 (14%) | 384 (15%) | 0.75 |
| Relaxed Filter | 49 (58%) | 1699 (68%) | 0.8 |
Abbreviations are as follows: Ped = Pediatric, MCD= minimal change disease, FSGS= focal segmental glomerulosclerosis, CR = Complete Remission.