[Table/Fig-3]:
Type of Treatment | Study | Vitamin | Sex | Age | Number Of Patients | Topical | Systemic | Grading Scale |
---|---|---|---|---|---|---|---|---|
Chemo-therapy | Wadleigh RG et al., [9] | E | Not available | 53-67 yrs | 18 | 1 ml of vit E oil, 400 mg/ml, twice a day for five days | _ | WHO |
Azza A EI et al., [10] | E | Not available | < 12 yrs | 63 | 100 IU capsule to be emptied into oral cavity twice daily and followed for five days | 100 IU soft gel capsule to be swallowed twice daily and followed for five days |
WHO | |
Arash AS et al., [11] | E | Male: 41 Female: 35 |
≥ 18 yrs | 76 | I gm of vit E paste to be applied twice daily, two days before the treatment till at least 20 days after completion of each cycle | 200 mg of pills to be taken twice daily, two days before the treatment till at least 20 days after completion of cycle | WHO | |
Radiot-herapy | Ferreira PR et al., [14] | E | Male: 48 Female:6 |
Mean age 53.5 yrs | 54 | _ | 400 mg vit E for five days twice daily. Rinse for five minutes and then swallow. | EORTC/ RTOG |
HSCT | Ghoreshi Z et al., [15] | E | Male: 28 Female :32 |
≥10 yrs, Mean age 27 yrs | 60 | _ | 400 mg twice daily at seven days before BMT until 28 days after BMT | NCI-CTC |
Thornley I et al., [16] | E | Not available | Mean age 8 yrs | 168 | _ | 8 IU/Kg once daily if body weight<25 kg 400 IU/Kg once daily if body weight>25 kg. 3-5 days before conditioning and continued through day 27 after transplantation or discharge from HSCT unit, whichever occurred first. |
NCI-CTC | |
Cohen G et al., [17] | A | Male: 7 Female: 4 |
Mean age 34.8±9.8 yrs | 11 | Twice daily 0.25 mg of 0.1% tretinoin ointment. Duration was from the beginning of BMT conditioning regimen until day +21 post BMT. | _ | SETO et al. |