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. 2017 May 1;11(5):ZE06–ZE09. doi: 10.7860/JCDR/2017/26845.9905

[Table/Fig-3]:

Details of studies included in the review and dosages of vitamins used in treatment of oral mucositis during cancer treatment.

Type of Treatment Study Vitamin Sex Age Number Of Patients Topical Systemic Grading Scale
Chemo-therapy Wadleigh RG et al., [9] E Not available 53-67 yrs 18 1 ml of vit E oil, 400 mg/ml, twice a day for five days _ WHO
Azza A EI et al., [10] E Not available < 12 yrs 63 100 IU capsule to be emptied into oral cavity twice daily and followed for five days 100 IU soft gel capsule to be swallowed
twice daily and followed for five days
WHO
Arash AS et al., [11] E Male: 41
Female: 35
≥ 18 yrs 76 I gm of vit E paste to be applied twice daily, two days before the treatment till at least 20 days after completion of each cycle 200 mg of pills to be taken twice daily, two days before the treatment till at least 20 days after completion of cycle WHO
Radiot-herapy Ferreira PR et al., [14] E Male: 48
Female:6
Mean age 53.5 yrs 54 _ 400 mg vit E for five days twice daily. Rinse for five minutes and then swallow. EORTC/ RTOG
HSCT Ghoreshi Z et al., [15] E Male: 28
Female :32
≥10 yrs, Mean age 27 yrs 60 _ 400 mg twice daily at seven days before BMT until 28 days after BMT NCI-CTC
Thornley I et al., [16] E Not available Mean age 8 yrs 168 _ 8 IU/Kg once daily if body weight<25 kg
400 IU/Kg once daily if body weight>25 kg. 3-5 days before conditioning and continued through day 27 after transplantation or discharge from HSCT unit, whichever occurred first.
NCI-CTC
Cohen G et al., [17] A Male: 7
Female: 4
Mean age 34.8±9.8 yrs 11 Twice daily 0.25 mg of 0.1% tretinoin ointment. Duration was from the beginning of BMT conditioning regimen until day +21 post BMT. _ SETO et al.