Table 7.
Quantitative results obtained from the comparative analysis of DNA repair mechanisms in plants and humans. In the first column, the various ‘lemmas’ (annotations) for DNA repair and its subpathways are presented, accompanied with the corresponding GO terms. The 2nd column is referred to the number of the already characterized Homo sapiens (Hs) genes. The 3rd refers to those genes of the 2nd column that have orthologues (one or more) in Arabidopsis thaliana (At). The 4th column is just the percentage (those that have orthologues/all genes). Correspondingly, 5th–7th columns refer to Arabidopsis thaliana. Underlined (8th–9th column) are the ‘new’ genes identified from our analysis for Hsa and Atha respectively. BER, base excision repair. NER, nucleotide excision repair. MMR, mismatch repair. HR, homologous recombination. NHEJ, non-homologous end joining.
| 1. Mechanism (GO Term) |
2. # Hs Genes | 3. # Hs Genes That Have Orthologues in At | 4. % | 5. # At Genes | 6. # At Genes That Have Orthologues in Hs | 7. % | 8. # Suggested Genes Arisen from Our Analysis for Hs | 9. # Suggested Genes Arisen from Our Analysis for At |
|---|---|---|---|---|---|---|---|---|
|
DNA repair
GO:0006281 |
507 | 259 | 51.1 | 300 | 185 | 61.7 | 86 | 243 |
|
BER
GO:0006284 |
52 | 32 | 61.5 | 29 | 12 | 41.4 | 3 | 36 |
|
NER
GO:0006289 |
124 | 59 | 47.6 | 30 | 21 | 70.0 | 5 | 57 |
|
MMR
GO:0006298 |
43 | 14 | 32.6 | 17 | 12 | 70.6 | 0 | 1 |
|
HR
GO:0000724 |
162 | 76 | 46.9 | 50 | 37 | 74.0 | 38 | 87 |
|
NHEJ
GO:0006303 |
73 | 9 | 12.3 | 7 | 4 | 57.1 | 0 | 8 |
| Total number of ‘DNA repair’ genes associated with “new roles” arisen from this analysis (see Figure 8 and Figure 9) | 95 | 281 | ||||||
| Total number of “entirely new” genes that have arisen from this analysis after the comparison with the “previously established” DNA repair genes | 84 | 234 | ||||||