Table 2. Further Evaluation of Test Compounds with Multitargeted Activity as MT-Stabilizing Agents and/or Inhibitors of COX and 5-LOX Pathways.

^aAll concentration–response analyses were conducted at multiple concentrations with triplicate samples per concentration.

^bThe change in AcTub was assessed as described in Table 1. ^#, Study conducted after a 5 mg/kg i.p. injection of test compound. ^∧, Study conducted after a 2 mg/kg i.p. injection of test compound with drug concentrations adjusted proportionally upward to allow comparison to 5 mg/kg doses. ND, not determined. NS, not significant. ± errors represent standard deviations. All analyses were conducted with groups of three mice.