TABLE 2.
AST results of the Accelerate Pheno system compared to culture-based ASTa
| Antimicrobial agent | Accelerate Pheno system AST |
Culture-based AST (no.) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| No. of AST results | No. (%) of category agreements |
No. (%) of minor discrepancies | No. (%) of major discrepancies | No. (%) of very major discrepancies | Susceptible | Resistant | |||
| S | R/I | Total | |||||||
| SAM | 66 | 31 | 32 | 63 (95.5) | 0 (0) | 3 (8.8) | 0 (0) | 34 | 32 |
| TZP | 91 | 78 | 6 | 84 (92.3) | 0 (0) | 7 (8.2) | 0 (0) | 85 | 6 |
| FEP | 90 | 73 | 6/1* | 80 (88.9) | 7 (7.8) | 3 (3.6) | 0 (0) | 83 | 6/1* |
| CRO | 85 | 75 | 8 | 83 (97.6) | 0 (0) | 2 (2.6) | 0 (0) | 77 | 8 |
| ETP | 85 | 85 | 0 | 85 (100) | 0 (0) | 0 (0) | 0 (0) | 85 | 0 |
| MEM | 94 | 91 | 2 | 93 (98.9) | 1 (1.1) | 0 (0) | 0 (0) | 91 | 3 |
| AMK | 95 | 91 | 2 | 93 (97.9) | 1 (1.1) | 0 (0) | 1 (33.3) | 92 | 3 |
| GEN | 94 | 84 | 9 | 93 (98.9) | 0 (0) | 1 (1.2) | 0 (0) | 85 | 9 |
| TOB | 94 | 82 | 10 | 92 (97.9) | 1 (1.1) | 1 (1.2) | 0 (0) | 84 | 10 |
| CIP | 94 | 69 | 21 | 90 (95.7) | 4 (4.3) | 0 (0) | 0 (0) | 73 | 21 |
| CST | 88 | 85 | 0 | 85 (96.6) | 0 (0) | 3 (3.4) | 0 (0) | 88 | 0 |
| Total | 976 | 844 | 97 | 941 (96.4) | 14 (1.4) | 20 (2.3) | 1 (1.0) | 876 | 100 |
The overall category agreement was 96.4%. Minor discrepancies, major discrepancies, and very major discrepancies were detected in 1.4, 2.3, and 1.0%, respectively. *, One strain showed an intermediate result for FEP in the Accelerate Pheno system and culture-based ASTs. AMK, amikacin; SAM, ampicillin-sulbactam; FEP, cefepime; CRO, ceftriaxone; CIP, ciprofloxacin; GEN, gentamicin; MEM, meropenem; TZP, piperacillin-tazobactam; TOB, tobramycin; CST, colistin; ETP, ertapenem. S, susceptible; R/I, resistant/intermediate.