TABLE 2.
Comparison of the InBios and Euroimmun Zika IgM ELISAs to the CDC Zika MAC-ELISA using retrospective clinical specimens
| ELISA | Result | CDC Zika MAC-ELISA |
Positive % agreement (95% CI) | Negative % agreement (95% CI) | Overall % agreement (95% CI) | Kappa (95% CI), assessment | ||
|---|---|---|---|---|---|---|---|---|
| No. presumptive positive | No. negative | No. otherb | ||||||
| InBios Zika MAC | Positivea | 27 | 0 | 1 | 93.1 (77–99.2) | 95.7 (77.3–100) | 90.7 (79.7–96.4) | 0.83 (0.69–0.96), excellent |
| Negative | 1 | 22 | 1 | |||||
| Otherb | 1 | 1 | 0 | |||||
| Euroimmun Zika | Positive | 6 | 0 | 0 | 20.7 (9.5–38.8) | 95.7 (77.3–100) | 51.9 (38.9–64.6) | 0.15 (0.02–0.29), poor |
| Negative | 23 | 22 | 2 | |||||
| Otherb | 0 | 1 | 0 | |||||
a
The positive category for the InBios Zika MAC-ELISA includes both presumptive Zika positive and possible Zika positive results.
b
Other indicates result of inconclusive for the CDC Zika MAC-ELISA, borderline for the Euroimmun Zika IgM ELISA, and other flavivirus positive for the InBios Zika MAC-ELISA.