TABLE 1.
Canonical OPV mutations associated with phenotypic reversion identified by deep sequencinga
| Vaccine strain | Mutation(s) (amino acid change)b |
||
|---|---|---|---|
| 5′ UTR | VP1 | VP3 | |
| Sabin 1 | G480A, T525C | A2795G (Thr106Ala), T2879C (Phe134Leu) | A2438T (Met225Leu) |
| Sabin 2 | A481G | T2909C (Ile143Thr) | |
| Sabin 3 | T472C | C2493T (Thr6Ile) | T2034C (Phe91Ser) |
a
Substitutions are from the reference Sabin sequence to the change associated with phenotypic reversion.
b
Nucleotide changes are numbered according to the position in the complete genome. Amino acid changes (in parentheses) are numbered according to the position in the protein after polyprotein cleavage.