TABLE 2.
Clade and patient no. | Species | PEN |
MTZ |
CLI |
PIP-TAZ |
VAN |
CTX |
CIP |
MRP |
TET |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MIC (mg/liter) | Res. genes | MIC (mg/liter) | Res. genes | MIC (mg/liter) | Res. genes | MIC (mg/liter) | Res. genes | MIC (mg/liter) | Res. genes | MIC (mg/liter) | Res. genes | MIC (mg/liter) | Res. genes | MIC (mg/liter) | Res. genes | MIC (mg/liter) | Res. genes | ||
Clade I | |||||||||||||||||||
10 | B. breve | 0.25 | >256 | 0.064 | 0.25 | 0.50 | 1 | 1 | mfd, gyrA | 1 | 1 | ||||||||
7 | B. breve | 0.25 | >256 | 0.016 | 0.064 | 0.25 | 8 | >32 | mfd, gyrA | 1 | 32 | tet(T) | |||||||
Clade II | |||||||||||||||||||
14 | B. longum subsp. infantis | 0.125 | 32 | 0.25 | 0.064 | 0.25 | 0.25 | 4 | mfd, gyrA | 0.016 | 4 | ||||||||
15 | B. longum subsp. infantis | 0.125 | 32 | 0.25 | 0.064 | 0.25 | 0.25 | 4 | mfd, gyrA | 0.016 | 4 | ||||||||
13 | B. longum subsp. infantis | 0.125 | 16 | 0.25 | 0.064 | 0.25 | 0.25 | 4 | mfd, gyrA | 0.016 | 4 | ||||||||
4 | B. longum subsp. infantis | 0.25 | >256 | 0.064 | lmrD | 0.125 | 0.25 | 0.50 | >32 | mfd, gyrA | 0.064 | 1 | |||||||
Clade III | |||||||||||||||||||
12 | B. longum subsp. longum | 0.50 | >256 | 0.125 | 1 | 0.50 | 0.50 | 0.5 | mfd, gyrA | 1 | 32 | ||||||||
9 | B. longum subsp. longum | 0.50 | >256 | 0.064 | 0.5 | 0.50 | 1 | >32 | mfd, gyrA | 0.25 | 0.50 | ||||||||
3 | B. longum subsp. longum | 0.50 | AIE | 8 | 0.064 | 0.50 | 0.25 | 1 | AIE | >32 | mfd, gyrA | 0.50 | 1.0 | AIE | |||||
5 | B. longum subsp. longum | 0.25 | 8 | 0.032 | 0.25 | 0.50 | 0.50 | >32 | mfd, gyrA | 0.064 | 0.50 | ||||||||
6 | B. longum subsp. longum | 0.25 | 8 | 0.064 | 1 | 0.25 | 1 | >32 | mfd, gyrA | 0.125 | 0.50 | ||||||||
2 | B. longum subsp. longum | 0.50 | >256 | >256 | 0.5 | 0.25 | 1 | >32 | mfd, gyrA | 0.25 | 1.0 | ||||||||
1 | B. longum subsp. longum | 0.50 | 8 | 0.064 | 0.25 | 0.25 | 1 | >32 | mfd, gyrA | 0.125 | 0.50 | ||||||||
Clade IV | |||||||||||||||||||
11 | B. animalis | 0.25 | 8 | 0.032 | 0.25 | 0.50 | 0.50 | 0.5 | mfd, gyrA-gyrB | 0.064 | 16 | tet(T) | |||||||
8 | B. animalis | 0.50 | 128 | 0.032 | 0.50 | 1 | 2 | >32 | mfd, gyr-gyrB | 0.125 | 16 | tet(T) |
PEN, penicillin; MTZ, metronidazole; CLI, clindamycin; PIP-TAZ, piperacillin-tazobactam; VAN, vancomycin; CTX, cefotaxime; CIP, ciprofloxacin; MRP, meropenem; TET, tetracycline; Res. genes, groups of genes presumed to predict resistance (Comprehensive Antibiotic Resistance Database [CARD]); AIE, antibiotic inactivation enzymes (encompasses several enzymes that catalyze the inactivation of an antibiotic); lmrD, lincomycin resistance gene; mfd, mutation frequency decline gene involved in strand-specific DNA repair (overexpression may lead to ciprofloxacin resistance); gyrA, Mycobacterium tuberculosis gyrA mutant; gyrB, Mycobacterium tuberculosis gyrB mutant; tet(T), tetracycline resistance gene.