Table 2.
Average number of affected individuals in the simulated pedigrees by model and degree of relatedness/cancer type
| Claus | IBIS | BRCAPRO | BOADICEA | |
|---|---|---|---|---|
| Low risk | ||||
| BR-FDR | 0.28 | 0 | 0.4 | 0 |
| BR-SDR | 0.9 | 0.26 | 0.76 | 0.48 |
| BR-TDR | 0.88 | 1.02 | 0.78 | |
| OV-FDR | 0.16 | 0.2 | 0.36 | 0.08 |
| OV-SDR | 0.48 | 0.98 | 0.54 | |
| OV-TDR | 0.76 | 0.88 | 0.4 | |
| Total affected | 1.34 | 2.58 | 4.4 | 2.28 |
| Moderate risk | ||||
| BR-FDR | 0.58 | 0.08 | 0.56 | 0.56 |
| BR-SDR | 1.02 | 0.88 | 0.98 | 0.88 |
| BR-TDR | 1.12 | 0.98 | 1.12 | |
| OV-FDR | 0.14 | 0.16 | 0.6 | 0.18 |
| OV-SDR | 0.48 | 1.14 | 0.62 | |
| OV-TDR | 0.5 | 1.08 | 0.64 | |
| Total affected | 1.74 | 3.22 | 5.34 | 4.00 |
| High risk | ||||
| BR-FDR | 0.68 | 0.62 | 0.66 | 0.76 |
| BR-SDR | 1.64 | 1.02 | 1.14 | 1.46 |
| BR-TDR | 0.88 | 1.12 | 1.06 | |
| OV-FDR | 0.46 | 0.3 | 0.82 | 0.34 |
| OV-SDR | 0.7 | 1.54 | 0.9 | |
| OV-TDR | 0.74 | 1.02 | 0.74 | |
| Total affected | 2.78 | 4.26 | 6.3 | 5.26 |
IBIS, International Breast Intervention Study; BOADICEA, Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm; BR-FDR, first-degree relative with breast cancer; BR-SDR, second-degree relative with breast cancer; BR-TDR, third-degree relative with breast cancer; OV-FDR, first-degree relative with ovarian cancer; OV-SDR, second-degree relative with ovarian cancer; OV-TDR, third-degree relative with ovarian cancer.
The rows labeled “total affected” indicate average number of total affected with either cancer and across all degrees of relatedness.