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Placental mTOR folate sensing may link low maternal folate to FGR. We propose that the PCFT senses low maternal folate concentrations and inhibits placental mTOR, which results in a decrease in placental amino acid transport, protein synthesis, and mitochondrial respiration. As a consequence, fetal nutrient availability is reduced, resulting in FGR. FGR, fetal growth restriction; mTOR, mechanistic target of rapamycin; PCFT, proton-coupled folate transporter.
