Table 2a.
Associations of telomere-related SNP, genetic risk scores, and short telomere length allele counts with pancreatic cancer risk: Additive model (cases: n=1,500; controls: n=1,499)
| Unadjusted model | Age- and sex-adjusted | Multivariable-adjusted a | |||||
|---|---|---|---|---|---|---|---|
| SNP ID | MAF | OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value |
| rs10936599 | 0.261 | 0.89 (0.79, 0.99) | 0.044 | 0.89 (0.79, 0.99) | 0.046 | 0.94 (0.83, 1.06) | 0.294 |
| rs2736100 | 0.492 | 1.12 (1.01, 1.24) | 0.023 | 1.13 (1.02, 1.24) | 0.021 | 1.09 (0.99, 1.22) | 0.100 |
| rs7675998 | 0.210 | 1.03 (0.91, 1.17) | 0.621 | 1.03 (0.91, 1.17) | 0.599 | 1.05 (0.93, 1.20) | 0.459 |
| rs9420907 | 0.143 | 0.98 (0.85, 1.13) | 0.775 | 0.98 (0.85, 1.13) | 0.763 | 1.02 (0.88, 1.18) | 0.838 |
| rs6772228 | 0.048 | 1.15 (0.91, 1.45) | 0.242 | 1.15 (0.91, 1.45) | 0.245 | 1.09 (0.85, 1.40) | 0.477 |
| rs8105767 | 0.295 | 1.02 (0.91, 1.13) | 0.763 | 1.02 (0.91, 1.14) | 0.752 | 1.02 (0.92, 1.15) | 0.690 |
| rs11125529 | 0.140 | 1.02 (0.88, 1.18) | 0.773 | 1.02 (0.88, 1.18) | 0.787 | 1.00 (0.86, 1.16) | 0.975 |
| rs3027234 | 0.231 | 1.03 (0.91, 1.16) | 0.662 | 1.03 (0.91, 1.15) | 0.677 | 1.04 (0.92, 1.18) | 0.500 |
| GRS Quartiles | Case: control | ||||||
| 1: ≤ 0.473 | 378: 370 | 1.00 (ref) | 0.588 | 1.00 (ref) | 0.585 | 1.00 (ref) | 0.556 |
| 2: > 0.473 - ≤ 0.567 | 337: 368 | 0.90 (0.73, 1.10) | 0.90 (0.73, 1.10) | 0.90 (0.73, 1.12) | |||
| 3: > 0.567 - ≤ 0.662 | 385: 372 | 1.01 (0.83, 1.24) | 1.01 (0.83, 1.24) | 1.04 (0.84, 1.28) | |||
| 4: > 0.662 | 383: 369 | 1.02 (0.83, 1.24) | 1.02 (0.83, 1.25) | 1.04 (0.84, 1.29) | |||
| Continuous b | 1.02 (0.97, 1.07) | 0.492 | 1.02 (0.97, 1.07) | 0.483 | 1.03 (0.97, 1.08) | 0.325 | |
| Short Allele Counts c | |||||||
| 2-6 | 434: 435 | 1.00 (ref) | 0.137 | 1.00 (ref) | 0.137 | 1.00 (ref) | 0.117 |
| 7 | 329: 369 | 0.89 (0.73, 1.09) | 0.89 (0.73, 1.09) | 0.88 (0.71, 1.09) | |||
| 8 | 362: 315 | 1.15 (0.94, 1.41) | 1.15 (0.94, 1.41) | 1.16 (0.94, 1.43) | |||
| ≥ 9 | 358: 360 | 1.00 (0.82, 1.21) | 1.00 (0.82, 1.23) | 1.02 (0.82, 1.25) | |||
| Continuous b | 1.02 (0.98, 1.07) | 0.380 | 1.02 (0.98, 1.07) | 0.375 | 1.03 (0.98, 1.07) | 0.264 | |
a
Adjusted for age (continuous), sex, self-reported personal history of diabetes (yes, no), smoking history (never, former, current), and usual adult body mass index (continuous)
b
Calculated as per 0.10 increase in kilobase pair of telomere length or per 1 short TL allele
c
Allele counts were categorized based on distribution among controls. Lower “short allele count” values predict longer telomere length (3).
Abbreviations: CI, confidence interval, GRS, genetic risk score, MAF, minor allele frequency (among controls), OR, odds ratio, SNP, single nucleotide polymorphism