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. 2017 Jun 26;8:708. doi: 10.3389/fimmu.2017.00708

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Copyright © 2017 Cui, Liu, Wang, Chen, Du, Zhao, Zhang, Liu, Tong and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model of Brucella Omp25-mediated inhibition of interleukin (IL)-12 production in human monocyte/macrophages. Brucella Omp25 inhibits TLR agonist-induced IL-12 p35 and p40 subunits at both the transcriptional and posttranscriptional levels via activating programmed death-1 (PD-1) signaling and upregulating miR-21-5p, miR-23b and miR-155, together resulting in a decreased IL-12 production in human monocyte/macrophages.