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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Cancer Res. 2016 Jun 2;76(15):4525–4534. doi: 10.1158/0008-5472.CAN-16-1040

Fig. 3. Effects of benzyl-4-piperidone compounds on growth and apoptosis in EWS pre-clinical models.

Fig. 3

(A) Four EWS cell lines were treated with b-AP15 or VLX1570 for 96 h and the relative number of viable cells was then determined. Results represent the mean ± SE of 3–5 experiments in which each condition was assayed in triplicate. (B) Four EWS cell lines were treated with b-AP15 or VLX1570 for 48 h and then caspase 3/7 activity measured. Results are the mean ± SD of 2–4 experiments in which each condition was assayed in triplicate. (C) Athymic mice bearing A673 or TC-71 xenografts were treated daily with vehicle, b-AP15 or VLX1570. Tumors were measured twice per week. *Significantly different compared to vehicle-treated group (Two way ANOVA, p<0.001 compared to vehicle-treated group).