Table 1.
Weight-related parameters and serum biochemical levels in mice.
| Parameter | Control | HFD+HFL | 5 mg/kg/d Xyloketal B | 10 mg/kg/d Xyloketal B | 20 mg/kg/d Xyloketal B | 15 mg/kg/d Atorvastatin |
|---|---|---|---|---|---|---|
| Body weight (g) | 21.84 ± 0.74 b | 31.92 ± 0.37 | 24.25 ± 0.65 b | 26.44 ± 0.94 b | 26.34 ± 0.44 b | 26.04 ± 0.80 b |
| Liver/body weight (%) | 4.40 ± 0.10 b | 5.38 ± 0.12 | 3.83 ± 0.23 b | 3.65 ± 0.24 b | 3.81 ± 0.09 b | 3.80 ± 0.11 b |
| Body weight/height (%) | 0.77 ± 0.02 b | 1.12 ± 0.02 | 0.85 ± 0.02 b | 0.95 ± 0.05 b | 0.94 ± 0.02 b | 0.90 ± 0.03 b |
| Visceral fat (g) | 0.49 ± 0.74 b | 1.11 ± 0.37 | 0.73 ± 0.65 b | 0.69 ± 0.94 b | 0.51 ± 0.44 b | 0.35 ± 0.80 b |
| Glucose (mmol/L) | 6.87 ± 0.53 a | 11.00 ± 0.57 | 7.33 ± 0.91 a | 7.64 ± 0.41 a | 7.83 ± 0.73 a | 9.98 ± 0.64 |
| ALT (mmol/L) | 35.50 ± 2.11 a | 43.80 ± 2.40 | 29.25 ± 1.21 b | 30.88 ± 1.23 b | 32.38 ± 1.50 b | 35.29 ± 2.00 a |
| AST (mmol/L) | 118.40 ± 3.12 a | 131.70 ± 5.79 | 110.17 ± 5.84 a | 115.00 ± 6.26 | 125.40 ± 7.26 | 110.25 ± 2.87 a |
| Triglyceride (mmol/L) | 0.96 ± 0.02 a | 1.26 ± 0.10 | 0.71 ± 0.02 b | 0.73 ± 0.07 b | 0.77 ± 0.04 b | 0.78 ± 0.01 b |
| Cholesterol (mmol/L) | 1.97 ± 0.06 b | 3.95 ± 0.32 | 2.22 ± 0.34 b | 2.55 ± 0.25 b | 2.53 ± 0.14 b | 1.87 ± 0.19 b |
| LDL cholesterol (mmol/L) | 0.10 ± 0.01 b | 0.87 ± 0.04 | 0.55 ± 0.07 b | 0.50 ± 0.09 b | 0.37 ± 0.04 b | 0.32 ± 0.03 b |
| HDL cholesterol (mmol/L) | 1.20 ± 0.03 a | 1.56 ± 0.10 | 1.36 ± 0.07 a | 1.54 ± 0.07 | 1.52 ± 0.08 | 1.65 ± 0.06 |
| APOE (mmol/L) | 12.53 ± 0.55 b | 3.17 ± 0.88 | 8.53 ± 1.28 | 17.49 ± 1.05 b | 16.60 ± 1.74 b | 4.71 ± 1.13 |
Data are expressed as the means ± SEM (n = 8), a p < 0.05, b p < 0.001 compared with mice fed the HFD+HFL.