Figure 5.

Imaging studies in rodents; n = 4–8 Sprague–Dawley rats; 27 vehicle = 10% polysorbate 80 in 0.5% methyl cellulose; 27 dosed 30 min prior to [¹⁸F]-41 (IV). (A) Representative images of [¹⁸F]-41 by increasing oral doses of 27. (B) mGlu₅ RO obtained with [¹⁸F]-41 and increasing oral doses of 27. (C) Unbound maximum plasma concentration of 27 versus mGlu₅ RO. (D) Dose of 27 versus mGlu₅ RO; *normalized to the maximum displacement of [¹⁸F]-41.