. 2017 May 22;60(12):5072–5085. doi: 10.1021/acs.jmedchem.7b00410

Table 1. Initial Picolinamide Core Analogs of 9.

no.	mGlu₅ pIC₅₀ (±SEM)^a	mGlu₅ IC₅₀ (nM)^a	% Glu max^a^,^b
9	7.62 ± 0.03	24	1.2 ± 0.1
10	6.70 ± 0.15	200	1.2 ± 0.1
11	7.01 ± 0.09	98	1.3 ± 0.1
12	7.22 ± 0.23	60	1.4 ± 0.1
13	8.01 ± 0.16	10	1.3 ± 0.1

Calcium mobilization mGlu₅ assay; values are an average of n ≥ 3 independent experiments.

Amplitude of response in the presence of 30 μM test compound as a percentage of maximal response (100 μM glutamate); an average of n ≥ 3 independent experiments.