Table 4. Preliminary Rat PK Results Using Intravenous (IV) Dosing^a.

no.	mGlu5 IC50 (nM)b	t1/2 (min)c	MRT (min)c	Clp (mL/min/kg)c	VSS (L/kg)c
21d	20	105	39	34.2	1.6
22e	9.1	268	120	32.5	4.5
23f	9.3	404	80	43.7	6.6
26d	3.6	82	157	96	11
27d	11	390	93	19.3	1.8
28d	3.1	281	208	9.2	1.9
33f	33	229	191	6.2	1.2

^aAverage n = 2, male Sprague–Dawley rats; dose = 1.0 mg/kg.

^bCalcium mobilization mGlu₅ assay; values are an average of n ≥ 3 independent experiments.

^ct_1/2 = Terminal phase plasma half-life; MRT = mean residence time; Cl_p = plasma clearance; V_SS = volume of distribution at steady-state.

^dVehicle = 10% EtOH, 70% PEG 400, 20% saline.

^eVehicle = 10% EtOH, 60% PEG 400, 30% saline.

^fVehicle = 10% EtOH, 50% PEG 400, 40% saline.