Table 6. Rat and Cynomolgus Monkey Pharmacokinetics of Compounds 27 and 28^a.

	rat IV PKb				rat oral PKb
no.	t1/2 (min)c	MRT (min)c	Clp (mL/min/kg)c	VSS (L/kg)c	Tmax (min)d	Cmax (μM)d	AUC (μM·h)d	% Fd
27	390	93	19.3	1.8	30	4.34	14.6	53
28	281	208	9.2	1.9	90	3.33	38.0	71

	cynomolgus monkey IV PKe				cynomolgus monkey oral PKe
no.	t1/2 (min)c	MRT (min)c	Clp (mL/min/kg)c	VSS (L/kg)c	Tmax (min)d	Cmax (μM)d	AUC (μM·h)d	% Fd
27	302	163	15.5	2.5	180	1.72	7.32	44
28	563	303	13.3	4.0	120	1.36	6.43	35

^aOral vehicle = 10% polysorbate 80 in 0.5% methyl cellulose; IV vehicle = 10% EtOH, 70% PEG 400, 20% saline.

^bAverage n = 2 male Sprague–Dawley rats.

^ct_1/2 = Terminal phase plasma half-life; MRT = mean residence time; Cl_p = plasma clearance; V_SS = volume of distribution at steady-state.

^dT_max = time at which maximum concentration occurs; C_max = maximum concentration; AUC = area under the curve; F = bioavailability.

^eAverage n = 2 male cynomolgus monkeys.