FIG. 9.

σ1s determines the extent and severity of reovirus-induced apoptosis in the brain. The cortex, hippocampus, and thalamus were examined at 8 days post-intracranial inoculation (A). Active, cleaved caspase-3 was quantified by the number and size of caspase-3-positive apoptotic areas (E). C84-MA (σ1s⁻ SA⁺)-infected mice displayed reduced caspase-3 activation in the brain compared to σ1s⁺ control viruses (B to E) (original magnification, ×25). In panel E, each bar represents the average score from four to seven mice. Error bars indicate standard errors of the means. Statistical comparisons are shown in below the corresponding areas of the graph. NS, not significant.